PTGS2 and early-onset autosomal dominant Alzheimer disease: In a study focused on Alzheimer’s disease, baicalein decreased ferroptosis markers lipid ROS, 4-hydroxynonenal, and COX2 (cyclooxygenase-2) and inhibited the expression of 12/15-LOX in a HT22 cell model of iron-induced injury, which was also validated in a mouse model of posttraumatic epilepsy [98].