Originally described in 1938 [7], CF is a life-limiting inherited multi-organ disease due to one of over 2000 gene mutations of cystic fibrosis transmembrane conductance regulator (CFTR) gene leading to the dysfunction or absence of the CFTR protein, a membrane anion channel that regulates the transepithelial ion flow vital to maintaining the proper ion and water transport and epithelial surface hydration [4,8,9,10,11]. Here, CFTR is linked to cystic fibrosis.