The percent of IgA/IgG-coated bacteria was elevated in IBD. FMT shifted the IgA-enriched bacteria to that of the donors [61]. Route of FMT (oral or colonoscopy) did not influence the pattern of IgA/IgG-coated bacteria. Diversity of the IgA-biome at 4 weeks after FMT was more diverse and the diversity correlated with clinical response in UC [62]. Of the donor taxa only Osoribacter splanchnicus was significantly correlated with clinical improvement in one study [62]. The IgA-biome is effective in preventing colitis in mice exposed to dextran-sodium-sulfate (DDS), an IBD model [32,63]. This evidence concerns the gene CD79A and irritable bowel syndrome.