Studies evaluating the effect of lactobacilli strains with the capacity to reduce the severity of intestinal infections found that the most remarkable effect was the increase in the intestinal levels of TNF-α, IFN-γ, IL-1β, IL-6, and IL-12 for the mice treated with the probiotic strains, as well as the phagocytic activity of intestinal and peritoneal macrophages [47,48]. Here, TNF is linked to digestive system infectious disorder.