To screen which clinical parameters were most associated with the metabolites changes during the oral glucose load, we performed a correlation matrix including markers of hyperglycemia, insulin resistance, and insulin production (glucose AUCOGTT, HbA1c, fasting glucose, HOMA-IR, insulin AUCOGTT, Matsuda index, Insulinogenic index), obesity markers (BMI, FFA AUCOGTT, liver fat percentage), and age (Figure 4). Here, INS is linked to obesity due to melanocortin 4 receptor deficiency.