CD8A and neoplasm: Principal T cells with anti-tumor activity (i.e., Th1 cells) are characterized by the ability to promote cell-mediated CD8+ cytotoxic T lymphocyte (CTL) generation, classical macrophage (M1) and neutrophil (N1) activation as well as the activation of other effector cells with cytotoxic potential such as NK cells, NKT cells, and γδ T cells [3,4].