In particular, “hot” (or immune-inflamed) tumors are characterized by higher tumor immunogenicity and better anti-tumor immune responses, principally due to: (i) significant accumulation of immune cells with cytotoxic and cytostatic activity, with immune cells appearing adjacent to tumor cells [9,13]; (ii) the expression of immune cell-attracting molecules such as CCL5 and CXCL9 [14]; and (iii) a type I interferon (IFN) transcriptional signature with important implications for cancer cell growth control [15]. Here, CCL5 is linked to neoplasm.