They showed that it could reduce MDA, NO, MPO, hydroxyproline, TNF-α, IL-1β, IL-6, iNOs mRNA, COX-2 mRNA, IFN-γ mRNA, Bcl-2-associated X protein (Bax), Caspase-1, NF-kB and IκBα and increase IL-10, SOD and GSH in an in vivo model of TNBS-induced colitis. Here, BAX is linked to colitis.