Moreover, the intestinal cells have up-regulation of pro-inflammatory chemokines like C-X-C motif chemokine ligand (CXCL) 1 (CXCL1), CXCL3, and CXCL8, which only perpetuates the inflammatory cycle of colitis [89,90,91,92]. The gene discussed is CXCL1; the disease is colitis.