The induced colitis decreased the weight of the mice and the size of the colon, and an increase in DAI, ulceration, loss of crypts, and infiltration of inflammatory tissue cells, and augmented the expression of COX-2, iNOS, IL-6, TNF-α, cellular proto-oncogene Fos (c-FOS), p65, Signal transducer and activator of transcription 1 (STAT1), and STAT3. This evidence concerns the gene PTGS2 and colitis.