Our data suggest conservation of the functional role of fmo-2 (flavin-containing monooxygenase) in progression of ARS, suggesting a possible mechanism of ARS along with a role of ionic factors in reorganization and reinforcement of lipid-membrane microdomains via downregulation of ABC transporter orthologues, as shown in Table 1. Here, ABCG2 is linked to Axenfeld-Rieger syndrome.