In conclusion, this research provides preclinical scientific evidence of the antihyperalgesic, antiallodynic, and anti-depressive effects of S. amarissima against fibromyalgia-type pain, partly due to the clerodane-type diterpene amarisolide A isolated from a medium polar extract involving more than one molecular target, such as serotonin 5-HT1A receptor and IL-1β. This evidence concerns the gene IL1B and fibromyalgia.