Curcumin’s anti-tumor activity is observed through regulation of multiple intracellular signaling pathways, including the phosphatidylinositol 3 kinase/Akt (PI3K/Akt) signaling pathway, nuclear factor kappa B (NF-κB) signaling, mitogen activated protein kinase (MAPK) signaling, p53 signaling, apoptosis and many other events. This evidence concerns the gene AKT1 and neoplasm.