As there was no blunting in the epinephrine response to recurrent hypoglycemia in STZ-diabetic rats, both chow-fed and keto-fed, the evidence for OX neurons adaptation to repetitive hypoglycemic stimulus in STZ-diabetic keto-fed rats is interesting and suggests a dissociation between the neuroendocrine counterregulation function and other functions of OX neurons, such as food seeking, locomotion and wakefulness. The gene discussed is HCRT; the disease is Hypoglycemia.