In order to maximise the relevance of our rat model of type 1 diabetes to the human condition, STZ-D chow-fed animals were supplemented with slow-release insulin implants for the duration of the study; this treatment did not normalise BG, but significantly reduced STZ-induced hyperglycemia (Figure 2A, 24.5 ± 1.4 mmol/L pre-implant vs. 10.8 ± 1.9 mmol/L one week post-implant, p < 0.0001). This evidence concerns the gene INS and type 1 diabetes mellitus.