This is in discordance with epinephrine release observed in 3×-Hypo group, which showed no diminution by an antecedent hypoglycemia, suggesting that attenuation of OX activation is not translated to the downstream sympathoadrenal response, and perhaps related to other physiological functions modulated by the OX neurons, such as arousal, exploration, and/or food seeking behaviour. The gene discussed is HCRT; the disease is Hypoglycemia.