SERPINA1 and Alpha-1-antitrypsin deficiency: Mutations of the genes involved in hemochromatosis, alpha 1-antitrypsin deficiency (SERPINA1), glycogen storage diseases (G6PC, SLC37A4), porphyries (HMBS, UROD), tyrosinemia (FAH), and Wilson’s Disease (ATP7B) increase the susceptibility to HCC [3,4,5,7,73].