Notably, a signature predicting DN and HCC progression, characterized by the overexpression of Csmd1, Dmbt1, Dusp1, and Gnmt oncosuppressor genes in DNs, and Bhmt, Dmbt1, Dusp1, Gadd45g, Gnmt, Napsa, Pp2ca, and Ptpn13 genes in HCCs of resistant rats, was identified. Here, GADD45G is linked to hepatocellular carcinoma.