LAG3 and neoplasm: The effect of overexpression of immune checkpoint molecules, as programmed death-1 (PD-1), cytotoxic T-lymphocyte antigen 4 (CTLA-4), lymphocyte activating gene 3 protein (LAG-3), and mucin domain molecule 3 (TIM-3), on tumor and immune cells and the high levels of immunosuppressive cytokines inducing T cell inhibition, may be an important mechanism of HCC immune escape [11].