Most liver preneoplastic lesions re-differentiate or do not further evolve to cancer, whereas the presence of predisposing factors can influence the course of the disease in a high proliferative class of patients: Hemochromatosis, Wilson disease, Tyrosinemia, alpha1-antitrypsin and glycogen storage diseases, HBC and HCV prevalence, and alcohol exposure, which are associated with poorer differentiation and high chromosomal instability. Here, SERPINA1 is linked to tyrosinemia.