PGD and cancer: Inhibition of 6PGD has been accounted to suppress tumor growth and induce cell death (by xenograft experimentation in nude mice with H1299, and K562 cells containing inducible 6-PGD shRNA construct in the presence of doxycycline) and sensitize cancer cells to chemotherapy (by exposing 6-PGD-depleted breast cancer cells and an in vivo xenograft mouse model to combined treatment with physion and paclitaxel) [16].