The IVW estimate revealed no obviously causal correlation between the risk of SLE and LDL cholesterol (OR: 0.998; 95% CI: 0.994, 1.001; p = 0.166) and Apolipoprotein B (OR: 0.998; 95% CI: 0.994, 1.001; p = 0.229). The gene discussed is APOB; the disease is systemic lupus erythematosus.