IVW estimates uncovered that genetically forecasted LDL cholesterol (Odds ratio OR: 1.131; 95% confidence interval CI: 0.838, 1.528; p = 0.420), HDL cholesterol (OR: 1.093; 95% CI: 0.884, 1.352; p = 0.412), triglycerides (OR: 0.903; 95% CI: 0.716, 1.137; p = 0.384), Apolipoprotein A-I (OR: 0.854; 95% CI: 0.680, 1.074; p = 0.177), and Apolipoprotein B (OR: 0.933; 95% CI: 0.719, 1.211; p = 0.605) were not causally related to risk of SLE (Table 1), consistent with the results of complementary analyses (Table 1). This evidence concerns the gene APOB and systemic lupus erythematosus.