Then, we explored the mechanism by which HIIT regulates the polarization of liver macrophages and found that HIIT could significantly increase the mRNA expression levels of RORα and KLF4 in T2DM mice, while RORα-induced upregulation of KLF4 expression is one of the key mechanisms mediating M2 polarization of KCs [22]. This evidence concerns the gene RORA and type 2 diabetes mellitus.