CACNA1A and spinocerebellar ataxia type 6: Apart from the Cav2.1 Ca2+ channel, K+ channels also play a crucial role in pacemaking activity [15,86], and it has been shown that the K+ channel blocker 4-AP was able to restore the precision of Purkinje cell pacemaking in the tottering mice [87] and in a mouse model of SCA6 [88].