Shin et al., compared effects of anti-VEGF treatment in different ocular conditions (including AMD) and concluded that loss of RNFL thickness was observed only in diabetic retinopathy and retinal vein occlusion concluding that retinal ischemia could be the main cause of RNFL loss rather than anti-VEGF treatment [22]. The gene discussed is VEGFA; the disease is age-related macular degeneration.