Based on the above findings, accumulating studies have shown that the NLRP3 inflammasome participates in a variety of kidney diseases, including diabetic nephropathy (DN), obesity-related kidney disease, acute kidney injury (AKI), crystal-related nephropathy, lupus nephritis (LN) and IgAN [7,8,9,10,12,14,15]. Here, NLRP3 is linked to liver dysplastic nodule.