Other studies have also shown that the renin–angiotensin–aldosterone system (RAAS) and endoplasmic reticulum stress (ERS) can regulate the NLRP3 inflammasome and play an important part in the development of renal diseases, including DN, obesity-related kidney disease and AKI [8,67,68,69,70]. The gene discussed is NLRP3; the disease is kidney disorder.