Other studies have also shown that the renin–angiotensin–aldosterone system (RAAS) and endoplasmic reticulum stress (ERS) can regulate the NLRP3 inflammasome and play an important part in the development of renal diseases, including DN, obesity-related kidney disease and AKI [8,67,68,69,70]. Here, NLRP3 is linked to acute kidney injury.