However, CRP and procalcitonin, as well as novel derived biomarkers such as neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and monocyte-to-lymphocyte ratio (MLR) were successfully used as severity markers in predicting complicated appendicitis in children [8,9,10,11]. This evidence concerns the gene CRP and appendicitis.