It was observed that patients with an elevated WBC count had a 5.54 higher likelihood of severe OI, elevated neutrophils (OR = 7.10), elevated lymphocyte count (OR = 8.62), elevated NLR with an odds ratio of 4.46 (p-value < 0.001), high CRP levels with a 6.65 higher likelihood of severe OI, and lastly, the CRP-NLR association being responsible for a 7.28 higher risk (95% CI = 4.83–10.16). This evidence concerns the gene CRP and osteogenesis imperfecta.