In analogy with another material that accomplished the effect of the controlled release of glucagon under the conditions of hyperinsulinemia [75], an aptamer or another ligand selectively binding insulin could be conjugated to glucagon and immobilized onto a polymer, so that, at a high insulin concentration in the medium, glucagon is released from the matrix through the competitive binding between free insulin and immobilized insulin, a concept similar in nature to the use of the transition between two manganese phases in this study to elicit the release of an insulin proxy. This evidence concerns the gene GCG and hyperinsulinism.