Risk factors that increase risk for future CV disease among women with a history of gestational diabetes include postpartum progression to type 2 diabetes mellitus; metabolic syndrome; obesity; hypertension; and altered levels of circulating inflammatory markers, specifically, adiponectin, C-reactive protein, and tumor necrosis factor-α [61]. The gene discussed is ADIPOQ; the disease is obesity due to melanocortin 4 receptor deficiency.