FGF-23 measured two days after symptom onset was associated with left ventricular remodeling (defined as a ≥20% increase in LV end-diastolic volume)—152.6 [102.5–241.3] vs. 75.8 [58.6–105.4] RU/mL, p = 0.002—a correlation which persisted after adjustments for established biomarkers of cardiac stress (NT-proBNP), myocardial necrosis (hs-cTnT), and inflammation (hs-CRP). This evidence concerns the gene FGF23 and Myocardial necrosis.