They further found that GWAS genes predominantly expressed in microglia in mice, such as APOE, CASS4, INPP5D, and HLA-DRB1, were found to be strongly expressed in vascular cells in humans; this suggests the hypothesis that some AD risk genes and pathways may have been evolutionarily transferred from microglia to the vasculature from mice to humans. The gene discussed is APOE; the disease is Alzheimer disease.