Human iPSCs with a mutation in the disrupted-in-schizophrenia 1 (DISC1) gene, which is a risk factor for a wide array of psychiatric illnesses, including schizophrenia, exhibit elevated WNT signaling activity with an altered expression of neuronal fate-related genes including an increased expression of dorsal progenitor markers and decreased expression of ventral progenitor markers [56,57]. The gene discussed is DISC1; the disease is schizophrenia.