Hence, there are sufficient plausible leads to posit that the NLRP3 inflammasome plays an important role in the pathophysiology of cerebrovascular disease, and the modulation (i.e., activation or blocking) of the NLRP3 inflammasome or caspase-1 may influence IL-1β synthesis and offer therapeutic avenues for cerebrovascular diseases, notably CSVD. The gene discussed is IL1B; the disease is cerebrovascular disorder.