ALDH1B1 and Glucose intolerance: The importance of ALDH1B1 in pancreatic stem cells has been validated by Anastasiou et al. (2016) by constructing mouse aldh1b1 knockout cell lines and demonstrating that the absence of ALDH1B1 led to an acceleration of the differentiation processes, dysregulation of beta cell-related factors, disruption of the function of beta cells and, ultimately, the induction of glucose intolerance [194].