AKT1 and colon adenocarcinoma: Similarly, Singh et al. (2015) revealed that the inhibition of ALDH1B1 attenuated the ability of SW 480 colon adenocarcinoma cells to form spheres in vitro and induce xenograft tumors in vivo while deregulating the Notch, Wnt/β-catenin and PI3K/Akt pathways [145].