CDH2 and melanoma: Normally, MC1R (melanocortin receptor 1) regulates the proliferation and survival of melanocytes and promotes DNA repair in case of damages caused by oxidative stress [56]; and (c) the altered expression of cell adhesion molecules, which causes the downregulation of E-cadherin and the upregulation of N-cadherin that contribute to the increase of migration, proliferation, and invasivity of melanoma cells [56].