In human hereditary spherocytosis, 93 different ANK1 gene mutations, including 12 missense and 27 nonsense mutations, have been reported (HGMD; accessed on 6 October 2022), whereas 23 mutations were identified in the ZZUD tandem of ankyrin-R, including eight variants located in subdomain ZU5A, seven in ZU5B, three in UPA (R1252X, R1334X, and L1340P), and five in the death domain. The gene discussed is ANK1; the disease is hereditary spherocytosis.