CRP and polycystic ovary syndrome: Regarding markers of low-grade inflammation, there was a strong association of increased BPA levels with markers of low-grade chronic inflammation (CRP, IL-6 and spleen enlargement) in PCOS group reported in a study by Tarantino et al. The authors thus hypothesized that besides the direct hepatotoxic and adipogenic effects, BPA could act as pro-inflammatory primer and therefore spleen enlargement could represent a marker of this process, possibly linked to the immune derangement in women with PCOS [94].