Well-known neuroendocrine dysfunction in PCOS—acceleration of the GnRH pulse generator activity and thus inappropriate gonadotropin synthesis and release, with elevated LH and low FSH level—leads to increased androgen production from theca cells and impaired compensatory aromatization to estrogens in the granulosa cells and impaired follicular development [102]. This evidence concerns the gene PLOD1 and polycystic ovary syndrome.