In case of gastrointestinal bleeding, transfusion is indicated when Hb < 7 g/dL with an aim of Hb 7–9 g/dL; if the patient requires large-volume paracentesis, 8 g of albumin should be administered per liter of fluid removed (independently of the total volume removed), and patients with AKI stage 2 or 3 should receive volume expansion with albumin 1 g/kg/24 h for 48 h. This evidence concerns the gene ALB and acute kidney injury.