In addition, L1-10 is a selective inhibitor of an angiogenic factor, angiopoietin-2 contributing to the progression of NASH, which decreased the inflammation, ballooning, and fibrosis in the liver with mice by inhibiting pathological vascular growth and endothelial cell dysfunction [30,31,32]. This evidence concerns the gene ANGPT2 and metabolic dysfunction-associated steatohepatitis.