MAPK8 and hepatocellular carcinoma: For example, anticancer drug apogossypolone (ApoG2) could activate the ROS/JNK/ERK signaling pathway to induce protective autophagy in human hepatocellular carcinoma (HCC) cells, and the use of antioxidant (N-acetylcysteine, NAC) increased the sensitivity of HCC cells to ApoG2 [146].