IL18 and neoplasm: For instance, Shan et al. (2007) and Shiga et al. (2015) demonstrate that whole-body low-dose irradiation (<1.5 Gy) enhances TLR4/MD2 and CD14 expression in murine peritoneal macrophages, thereby promoting secretion of anti-tumor cytokines (IL-12, IL-18), which indicates an increase in anti-tumor potential of these cells.