There is a large number of pathways which are potentially associated with breast cancer, such as apoptosis, ErbB, JAK-STAT, HIF-1, regulation of actin cytoskeleton, TNF, pathways in cancer, TCR, BCR, TLR signaling pathways, etc. In the case of the MCF10A network, JUN and FOS proteins infer a large number of critical signaling pathways but many fewer than PIK3R1 of MCF7, and there were less dense protein pathway connections than in MCF7. This evidence concerns the gene PIK3R1 and breast cancer.