PIK3R1 and cancer: There is a large number of pathways which are potentially associated with breast cancer, such as apoptosis, ErbB, JAK-STAT, HIF-1, regulation of actin cytoskeleton, TNF, pathways in cancer, TCR, BCR, TLR signaling pathways, etc. In the case of the MCF10A network, JUN and FOS proteins infer a large number of critical signaling pathways but many fewer than PIK3R1 of MCF7, and there were less dense protein pathway connections than in MCF7.