FUS is largely a soluble protein but forms cytoplasmic inclusion bodies in a range of FUS proteinopathies such as ALS-FUS in motor neuron disease or FTLD-FUS in frontotemporal lobar degeneration, etc. The FUS-induced neurotoxicity in ALS is rescued by RNAi-mediated depletion of hsrω lncRNAs in Drosophila [59]. The gene discussed is FUS; the disease is frontotemporal dementia.