EGFR and allergic asthma: In the case of Alternaria alternata, serine proteases have been shown to be at least partially involved in the development of allergic asthma [91]; however, for this fungus, both the PAR2-dependent mechanism and the PAR2-independent route based on epidermal growth factor receptor (EGFR) activation were recently shown to be responsible for the immune response and cytokine production by epithelial cells; albeit, all fungal factors involved in this process still need to be characterized in detail [105,106,107].