Comparing the effects of atranorin on normal mammary epithelial NMuMG cells and 4T1 cancer cells, it was observed that 4T1 cells were more sensitive to atranorin, reducing the clonogenic ability of carcinoma (75 μM), inducing apoptosis mediated by caspase-3 activation and poly ADP ribose polymerase (PARP) cleavage, and enhancing the depletion of Bcl-xL protein [57]. The gene discussed is CASP3; the disease is carcinoma.