There were no significant differences in gender, age, or etiology between the two groups in the training cohort, while there were significant differences in disease course, Child-Pugh score, Hb, Alb, PT, D-dimer, PVD, spleen length, spleen thickness, splenectomy, esophageal and gastric varices, and ascites between the two groups (p < 0.05). This evidence concerns the gene GSTM1 and Varicose veins.