No alterations of vessel morphology but increased systemic levels of VEGF-C in serum from lipedema patients and increased M2-polarized macrophage infiltration into lipedema adipose tissue were re-ported by Felmerer et al. [44], indicating a potential disturbance of the permeability properties in lipedema blood and lymphatic vasculature. This evidence concerns the gene VEGFC and Lipedema.