Next, we examined the SNV situation of these necroptosis risk model genes in pan-cancer, and the results showed that the top ten SNV variant genes were FLT3, HSP90AA1, PLK1, HSPA4, IDH2, LEF1, FASLG, PANX1, SLC39A7, and IPMK (Figure 6D,E). Here, HSPA4 is linked to cancer.