The role of necroptosis-related genes in breast cancer, such as FASLG, FLT3, HSPA4, IDH2, IPMK, LEF1, and SLC39A7, has not been extensively studied, and these necroptosis-related genes have been confirmed to regulate the biological processes of necroptosis in various types of tumors. This evidence concerns the gene LEF1 and breast cancer.