LEF1 and breast cancer: By using LASSO regression curve analysis to build a model consisting of BNIP3, CD40, FASLG, FLT3, HSP90AA1, HSPA4, IDH2, IPMK, LEF1, PANX1, PLK1, and SLC39A7, we were able to fully exploit the prognostic value of these necroptosis-related genes in breast cancer (Figure 3A,B).