Next, we examined the SNV situation of these necroptosis risk model genes in pan-cancer, and the results showed that the top ten SNV variant genes were FLT3, HSP90AA1, PLK1, HSPA4, IDH2, LEF1, FASLG, PANX1, SLC39A7, and IPMK (Figure 6D,E). The gene discussed is PLK1; the disease is cancer.