Moreover, the lack of significant association between sclerostin and Rel LTM, and between sclerostin and Hgb in multivariate analysis, and the presence of these relationships in univariate analysis does not preclude that there is a possible confounding effect of leptin in the relationship between sclerostin and decreased muscle mass presented as lower Rel LTM, and between sclerostin and anemia in non-dialysis CKD male patients. This evidence concerns the gene SOST and chronic kidney disease.