When SARS-CoV-2 reaches the site where it causes infection, CD38 may be involved in direct Ca2+ signaling, which has been shown to be important for viral endocytosis, regulating interferon-stimulated genes (ISGs), enhancing antiviral oxidative bursts from macrophages, orchestrating the deadly cytokine storm or hyperinflammatory response, and modulating exoenzymatic adenosinergic networks. This evidence concerns the gene CD38 and infection.