Different COVID-19 patients in asymptomatic/mild, moderate, and severe/critical groups also showed significant differences, as a decrease was recorded comparing them with the healthy control group, with p < 0.01, p < 0.05, and p < 0.01, respectively, and the lowest count of the CD8+CD38+ subtype was also recorded in the severe group. This evidence concerns the gene CD38 and COVID-19.