KRAS and non-small cell lung carcinoma: A phase 1b, multi-center study of binimetinib plus pemetrexed and cisplatin chemotherapy, followed by the maintenance of binimetinib and pemetrexed for advanced KRAS-mutant NSCLC, reported an ORR of 33%, a median PFS of 5.7 months, and a median OS of 6.5 months, with no unacceptable AEs [85].