A study found that PDAC cells regulate pH and glycolysis to increase carbonic anhydrase 9 (CA9) expression by stabilizing hypoxia inducible factor (HIF) 1-Alpha (HIF1A) and HIF2A during hypoxia; thus, the disruption of this pathway may slow the growth of PDAC xenograft tumors in mice, becoming a potential target pathway for pancreatic cancer [125]. The gene discussed is CA9; the disease is familial pancreatic carcinoma.