KRAS and colorectal carcinoma: In CRC, a retrospective study comparing KRAS G12C mutations to other KRAS mutations in metastatic CRC patients treated with first-line chemotherapy plus bevacizumab showed that KRAS G12C had a significantly worse response rate (RR) than other subtypes (p = 0.017), while no difference in PFS (p = 0.76) and OS (p = 0.56) was observed [44].