ANKS6 and cystic kidney disease: Cys1, Nphp3, Anks6 (also called Pkdr1/Nphp16), and Pkhd1 have since been identified as responsible for the development of renal cysts in murine strains in the cpk mouse, pcy mouse, Han:SPRD-Cy/+ rat (commonly known as the Cy rat), and PCK rat, respectively.