On the other hand, other players in the system, such as IGF binding protein 3 (IGFBP3), the GH-IGF system, and IGF-II receptors, prevent the induction of apoptosis, promote mitogenesis, and control IGF-I activities, which operate as tumor growth inhibitors [29,30,31,34,35,36] (Figure 1). Here, IGFBP3 is linked to neoplasm.