Finally, through a linear regression model, we analyzed the possible dependence of reverse remodeling, expressed as delta EDV% and calculated as (EDV1−EDV0)EDV0×100, from different factors such as age, sex, time from diagnosis of HF, baseline NT-proBNP, baseline furosemide dose, baseline degree of diastolic dysfunction, baseline LAV, follow-up time and final SV dose, aside with etiology (ischemic/non ischemic). The gene discussed is NPPB; the disease is hydrops fetalis.