TNFSF10 and cancer: Following these observations, and aiming to imitate the exosome-bound TRAIL, we successfully created, in previous works, artificial lipid nanoparticles containing TRAIL on their surface (LUV-TRAIL) with a higher in vitro cytotoxicity against several types of cancer cell lines, in comparison with soluble recombinant TRAIL, both in vitro and in vivo [10,21,22,23,24,25,26].