Following activation and/or priming through the aforementioned modalities, platelets release their α and dense granules and a variety of stored cytokines as shown by the experimental detection of increased FV and FXIII and platelet factor 4 release, CD40L, P-selectin exposure and IL-1 de novo synthesis (which partially mirrors the positive feedback mechanism in sepsis) [70,144,145]. This evidence concerns the gene IL1B and Sepsis.