In infectious diseases, the common endpoint is the activation of shared signaling pathways: nuclear factor kappa B (NF-κB)signaling, inflammasome signaling, mitogen-activatedprotein kinase (MAPK) signaling and TANK-binding kinase 1—interferon regulatory factor 3 (TBK1–IRF-3)signaling [10,11]. The gene discussed is TBK1; the disease is infectious disease.