David et al. revealed that HIF-1α could account for the accumulation of MDSCs in hepatocellular carcinoma (HCC) via chemokines (C-C motif ligand 26 (CCL26)) and maintenance by Ectonucleoside Triphosphate Diphosphohydrolase 2 (ENTPD2), which is a direct transcriptional target of HIF-1α [17]. The gene discussed is ENTPD2; the disease is hepatocellular carcinoma.