POLE and exstrophy-epispadias complex: In 2013, The Cancer Genome Atlas research network performed an integrated genomic and transcriptomic analysis of 373 endometrial carcinomas, including EEC and serous carcinoma, and classified them into four molecular subtypes with distinct prognoses: DNA polymerase epsilon (POLE) ultramutated (POLEmut) with an excellent prognosis, microsatellite instability (MSI) hypermutated with an intermediate prognosis, copy number-high with the worst prognosis, and copy number-low with an intermediate prognosis [10].