Based on the assessment of surrogate markers that are commonly measured in clinical practice, endometrial carcinomas are separately classified into four molecular subgroups that are analogous to the aforementioned classifications: POLEmut, mismatch repair (MMR)-deficient (MMRd), p53-mutant (p53mut), and tumors exhibiting none of these alterations that are referred to as having a non-specific molecular profile (NSMP), respectively [11]. Here, TP53 is linked to endometrial carcinoma.